No, when an erythema migrans occurs, it should definitely be treated with antibiotics. This skin condition is so typical, that even with a negative test result (missing antibodies in the blood) the therapy should begin, since the antibodies are often only much later verifiable.
If no erythema migrans has appeared, but the above-mentioned flu-like symptoms occur, the antibodies (IgM = early infection phase antibody, IgG = late infection phase antibody) are determined, as they may be a diagnostic tool.
If there are no physical dicomforts after a tick bite, no blood sample is recommended!
Because: 5 – 10% of the healthy population have a positive IgG (and / or IgM!), In some regions even 20% of adults.
Thus, a positive test result does not always indicate an active, “fresh” Lyme, but merely indicates that the immune system had contact with Borrelia at some point in life. After all, high antibody levels can be retained in the blood for many years after an earlier, possibly unnoticed infection.
In addition, the IgM antibodies are not necessarily specific for Borrelia. Non-specific means: there are detectable antibodies in the blood, which are directed according to laboratory expression against Borrelia, but de facto they show only an unspecific reaction of the immune system to another infection, which usually already has healed.
Other test methods, such as the lymphocyte transformation- test or antigen detection from the urine are not suitable for confirming the diagnosis of Lyme disease.